Optimist Skin for DNN by Considero.net offers 2 basic layout schemas: default and simple.
All the panes but the Content Pane are invisible. That means, they are visible only if there is some content in them. You can use default layout schema for simple layouts as well. Simple layout is there only to make the page lighter and easier to use if there is no need for more complex layout.
That gives the contetn manager opportunity to arrange the content in many different ways.
You can see the demo pages here.